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. On the custom menu select Driver Options, click on the tab Customer Name, and then select Input Customer Name by user name.A randomized, double-blind, placebo-controlled clinical trial of lorazepam added to oxybutynin for bladder control in spinal cord injury patients.
To evaluate the efficacy of lorazepam for bladder function in spinal cord injury patients. Randomized, double-blind, placebo-controlled, placebo-controlled study. Second level spinal cord injury outpatient clinic. Nine male ambulatory patients with unstable detrusor function. A double-blind, placebo-controlled study was conducted for 24 hours, including a urine collection and a voiding diary before and after 1.5 mg oral lorazepam or placebo was administered as an adjunct to oxybutynin. After dosing, the patients were monitored in a computer-generated bladder control study for 24 hours and a voiding diary kept. Each patient was premedicated with standard doses of oxybutynin and the study was double-blinded. The urinary production during the 24-hour dosing period was not different between the lorazepam and placebo groups. Similarly, there was no change in the duration and intensity of micturition with lorazepam or placebo. Moreover, although the desire to void was significantly greater with placebo, the desire to void was still decreased with lorazepam relative to placebo. For 6 patients, the cumulative voiding volume (area under the curve) was different between the two study groups. This was due to the placebo group voiding volume being 12 L or less than the pre-dose voiding volume while the lorazepam group increased their voiding volume on average by 5 L (P = 0.03). The cumulative voided volume in the lorazepam group was 35% greater than the placebo group, (P = 0.054). For two patients, the cumulative voided volume was >30 L in the placebo group while it was Combining molecular diagnostics and phenotype-driven drug development.
The identification of actionable mutations is a crucial component in the development of precision medicine. Clinical sequencing is a powerful tool for identifying new mutations causing
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