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We report the application of a microfluidic continuous-flow (CF) column as a novel tool to efficiently study the effect of small molecules on growth factor signaling pathways. The technology provides a continuous-flow microfluidic platform that integrates a deformable microfluidic device with an optical sensor for continuous monitoring of cell growth. This technology was used to probe the inhibition by colchicine of the TGF-beta and IGF-I signaling pathways in a time-dependent manner. The resulting outputs offer an effective tool to screen small molecules based on their ability to inhibit growth factor signaling and affect cell growth and survival.
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