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IgA deficiency among patients with lepromatous leprosy in a tertiary care center. IgA deficiency (IgAD) has been associated with leprosy in various ethnic groups. To determine the prevalence of IgAD among patients with leprosy in a tertiary care center in South India. Patients with leprosy (n = 134) attending the leprosy clinic at the Christian Medical College, Vellore were studied for IgAD by serum IgA ELISA. Standard WHO/RNTCP criteria were applied to classify the patients as pauci- or multibacillary (MB) leprosy. DNA for molecular studies was obtained from patients with MB leprosy. Dapsone and rifampicin treatment was given to all patients, except those with paucibacillary (PB) leprosy. ELISA tests were positive for IgAD in 52 (38.2%) of the 134 patients with leprosy. IgAD was more common among female patients (40.7%) than among male patients (29.4%). Among patients with PB leprosy, IgAD was present in 37.5% (4/16) of the patients. IgAD was associated with advanced age and gender, with the majority of the patients (54.3%) being over 60 years of age. IgAD was not associated with any of the dapsone and rifampicin treatment regimens, except for use of a shorter duration of rifampicin in those who were positive for IgAD. All patients with IgAD were on a long course (12-24 months) of dapsone treatment. Serum IgA levels did not correlate with PB leprosy. Thus, all patients with IgAD should be treated with dapsone and rifampicin. Given the high prevalence of IgAD among patients with PB leprosy and the lack of a clear association with a particular type of leprosy, it may be reasonable to treat all patients with leprosy with dapsone and rifampicin for the duration of treatment.

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Flowcharting: Create and draw freeform, organized graphical diagrams that show how a process should work. Lines and Polylines: Draw more precise lines and polygons than you have ever before. Lengthen and shorten, curve and straighten, concurve and bend, construct complex lines, and add fills and strokes. Symbols: Generate and use symbols without drawing them. Edit symbol properties directly in the symbol palette. Create dynamic symbols that change over time. (video: 1:35 min.) Graphical Layout: Rapidly drag and drop objects to place them on a drawing. Quickly resize and reposition items using a scrollable and resizable drawing viewport. Change the placement of multiple objects at once. (video: 1:55 min.) In addition, AutoCAD now supports DraftSight, one of our newest CAD/CAE applications. So if you need to send designs to 3D CAD software, or work with AutoCAD for CAD or CAE, the interface between AutoCAD and DraftSight is now even more seamless. This is a free download from the Autodesk Application Network. AutoCAD and AutoCAD LT: Changes in AutoCAD and AutoCAD LT If you are running AutoCAD or AutoCAD LT on Windows 10, you might notice that AutoCAD now has the Windows 10 interface. AutoCAD and AutoCAD LT are built for Windows 10, so there are a lot of new features that you will find in AutoCAD. The Windows 10 design mode and experience is familiar to users of other Windows versions such as Windows 7. It lets you easily view or edit your drawings. You can add shapes, lines, and text, and then easily save and export your work. All drawings are now also automatically saved using an online backup service. This lets you automatically back up your drawings to the cloud, even if you are not connected to the Internet. This helps to protect your drawings, even if you lose your Internet connection or your computer fails. AutoCAD and AutoCAD LT are also compatible with all of the latest Windows features, such as Windows Ink. You can also experience the Windows 10 design experience in AutoCAD. But, if you prefer the classic AutoCAD user interface, you can use either the AutoCAD Classic

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